학술논문
French national epidemiology of bacterial superinfections in ventilator-associated pneumonia in patients infected with COVID-19: the COVAP study
Document Type
Report
Author
Pichon, Maxime; Cremniter, Julie; Burucoa, Christophe; Abdallah, Sahar; Alauzet, Corentine; Alix, Tom; Allouche, Kahina; Amara, Marlène; Anglade, Florence; Anguel, Nadia; Armand-Lefevre, Laurence; Barbier, Francois; Beauruelle, Clémence; Bemer, Pascale; Benmansour, Hanaa; Bercot, Béatrice; Bergon, Ludovic; Bertei, Dominique; Berthon, Marc; Beuret, Pascal; Bientz, Léa; Billon, Laura; Bousquet, Aurore; Brousse, Amélie; Broutin, Lauranne; Bruneel, Fabrice; Cady, Anne; Camelena, Francois; Carrer-Causeret, Amélie; Caspar, Yvan; Chemali, Lotfi; Jaouen, Anne Christine; Cocherie, Théophile; Cointe, Aurélie; Corvec, Stephane; Courtellemont, Laura; Cuzon, Gaelle; Dao, Anne; Delbove, Agathe; D'Humieres, Camille; Djamdjian, Laura; Doloy, Alexandra; Dorin, Joséphine; Dumont, Yann; Dumoulard, Bruno; Sayed, Faten El; Fangous, Marie-Sarah; Favier, Laurent; Ferre, Alexis; Fortineau, Nicolas; Francois, Juliette; Gachet, Clémence; Gargouri, Mahmoud; Garot, Denis; Gastli, Nabil; Gauvin, Elena; Geneau, Isabelle; Geslain, Guillaume; Goury, Antoine; Grenot, Romaric; Grillon, Antoine; Guillard, Thomas; Guillouzouic, Aurélie; Guinard, Jerome; Guiraud, Jennifer; Gyde, Esther; Henry, Christophe; Jeannot, Katy; Kempf, Marie; Kouatchet, Achille; Landraud, Luce; Lanotte, Philippe; Larreche, Sebastien; Le Gallou, Brice; Le Breton, Elodie; Leblanc, Pierre-Etienne; Lecuyer, Hervé; Lemee, Ludovic; Lessard, Pauline; Leyssene, David; Lureau, Pierre; Manteaux, Anne-Elisabeth; Mervent, Michael; Micaelo, Maite; Michaud, Anthony; Moquet, Olivier; Muggeo, Anaelle; Ochin, Evelina; Ochocki, Patrick; Ouchikhe, Abdelali; Paluch, Maxime; Pancher-Lory, Marie; Pantel, Alix; Pastuszka, Adeline; Perruche, Ophélie; Peuchant, Olivia; Piau, Caroline; Plouzeau-Jayle, Chloé; Quesnel, Kevin; Richard, Lucie; Riverain, Emeline; Robert, Alexandre; Roux, Anne-Laure; Saint-Sardos, Pierre; Serpin, Laurent; Silva, Daniel; Sivadon-Tardy, Valerie; Toumert, Karim; Tournus, Céline; Touroult-Jupin, Pauline; Tran Quy, Antoine; Vachee, Anne; Vanjak, Christian; Vernet-Garnier, Véronique; Vinclair, Camille; Violette, Jérémie; Walewski, Violaine
Source
Annals of Clinical Microbiology and Antimicrobials. June 28, 2023, Vol. 22 Issue 1
Subject
Language
English
ISSN
1476-0711
Abstract
Author(s): Maxime Pichon[sup.1,2] , Julie Cremniter[sup.1,2] , Christophe Burucoa[sup.1,2] , Sahar Abdallah[sup.] , Corentine Alauzet[sup.] , Tom Alix[sup.] , Kahina Allouche[sup.] , Marlène Amara[sup.] , Florence Anglade[sup.] , Nadia Anguel[sup.] [...]
Background Description and comparison of bacterial characteristics of ventilator-associated pneumonia (VAP) between critically ill intensive care unit (ICU) patients with COVID-19-positive, COVID + ; and non-COVID-19, COVID-. Methods Retrospective, observational, multicenter study that focused on French patients during the first wave of the pandemic (March-April 2020). Results 935 patients with identification of at least one bacteriologically proven VAP were included (including 802 COVID +). Among Gram-positive bacteria, S. aureus accounted for more than two-thirds of the bacteria involved, followed by Streptococcaceae and enterococci without difference between clinical groups regarding antibiotic resistance. Among Gram-negative bacteria, Klebsiella spp. was the most frequently observed bacterial genus in both groups, with K. oxytoca overrepresented in the COVID- group (14.3% vs. 5.3%; p < 0.05). Cotrimoxazole-resistant bacteria were over-observed in the COVID + group (18.5% vs. 6.1%; p Conclusions The present study demonstrated that the bacterial epidemiology and antibiotic resistance of VAP in COVID + is different from that of COVID- patients. These features call for further study to tailor antibiotic therapies in VAP patients. Keywords: Ventilator-associated pneumoniae, Bacterial superinfection, Antibiotic resistance, Intensive care, COVID-19
Background Description and comparison of bacterial characteristics of ventilator-associated pneumonia (VAP) between critically ill intensive care unit (ICU) patients with COVID-19-positive, COVID + ; and non-COVID-19, COVID-. Methods Retrospective, observational, multicenter study that focused on French patients during the first wave of the pandemic (March-April 2020). Results 935 patients with identification of at least one bacteriologically proven VAP were included (including 802 COVID +). Among Gram-positive bacteria, S. aureus accounted for more than two-thirds of the bacteria involved, followed by Streptococcaceae and enterococci without difference between clinical groups regarding antibiotic resistance. Among Gram-negative bacteria, Klebsiella spp. was the most frequently observed bacterial genus in both groups, with K. oxytoca overrepresented in the COVID- group (14.3% vs. 5.3%; p < 0.05). Cotrimoxazole-resistant bacteria were over-observed in the COVID + group (18.5% vs. 6.1%; p Conclusions The present study demonstrated that the bacterial epidemiology and antibiotic resistance of VAP in COVID + is different from that of COVID- patients. These features call for further study to tailor antibiotic therapies in VAP patients. Keywords: Ventilator-associated pneumoniae, Bacterial superinfection, Antibiotic resistance, Intensive care, COVID-19