부산대학교 도서관

Injections of dominant negative N-cadherin RNA into the region of 2- to 4-cell Xenopus embryos help study the involvement of the cell adhesion molecule cadherin in the interaction of muscle progenitors in a community of 100 or more cells to stimulate their myogenic genes and the muscle differentiation pathway. The injections suppress MyoD expression in muscle progenitor cells while Xbra expression is unaffected, and levels of Xwnt-8 message increase with increasing doses of dominant negative cadherin RNA. MyoD blocking in embryos injected with the dominant negative cadherin mRNA reveals that the blocking occurs through the cadherin pathway and highlight the involvement of cadherin-mediated cell interactions in the signaling events required for muscle progenitor cell differentiation.