학술논문
A discrete subpopulation of human monocytes expresses a neutrophil-like proinflammatory (P) phenotype
Document Type
Academic Journal
Author
Source
The American Journal of Physiology. Dec, 1994, Vol. 267 Issue 6, pL775, 11 p.
Subject
Language
ISSN
0002-9513
Abstract
A neutrophil-like proinflammatory (P) phenotype is expressed in a discrete human monocyte subpopulation. These P monocytes adhere to extracellular matrix upon high-level cell-surface expression of specific integrins, release reactive oxygen species, constitute serine proteinases and alpha1-proteinase inhibitor and also exhibit proteolytic activity against a soluble peptide human leukocyte elastase substrate. Monocytes do not express cell surface HLA-DR antigen, and hence do not participate in specific immune responses.