학술논문
Effect of dexcloprostenol on endogenous prostaglandin F.sub.2[alpha] release in dairy heifers
Document Type
Report
Author
Source
Theriogenology. April 1, 2005, Vol. 63 Issue 6, p1659, 8 p.
Subject
Language
English
ISSN
0093-691X
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.theriogenology.2004.07.021 Byline: Juhani Taponen (a), Hans Kindahl (b) Keywords: Dairy heifer; Dexcloprostenol; Endogenous prostaglandin F2[alpha] release; Early diestrus Abstract: Cloprostenol was previously believed to be unable to release endogenous prostaglandin F.sub.2[alpha] (PGF.sub.2[alpha]) when administered during early bovine diestrus. A prostaglandin release is, however, seen in late diestrus. The aim of this study is to find out whether dexcloprostoenol (containing the only biologically active isomer, d-isomer, of cloprostenol) induces endogenous PGF.sub.2[alpha] release during early and late diestrus. Twelve heifers of the Finnish Ayrshire breed were allocated into two equal groups. Their estrous cycles were synchronized with dexcloprostenol. A further luteolysis was induced with 0.15mg of dexcloprostenol either on Day 7 (group D7 or early diestrus) or on Day 14 (group D14 or late diestrus) after ovulation. Blood for progesterone and the PGF.sub.2[alpha] metabolite 15-ketodihydro-PGF.sub.2[alpha] determinations was collected immediately before dexcloprostenol treatment and thereafter every second hour for 48h. Five of the six heifers in both groups showed significantly increased blood levels of 15-ketodihydro-PGF.sub.2[alpha] at some time during the 48-h experimental period. The intervals from treatment to the first significant increases of the PGF.sub.2[alpha] metabolite were 32.8[+ or -]2.3h (min. 30h, max. 36h) and 20.0[+ or -]4.2h (min. 14h, max. 24h) in groups D7 and D14, respectively (P Author Affiliation: (a) Department of Clinical Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, Saari unit, Pohjoinen pikatie 800, FI-04920 Saarentaus, Finland (b) Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine and Animal Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden Article History: Received 30 March 2004; Revised 24 June 2004; Accepted 24 July 2004