부산대학교 도서관

Although SARS-CoV-2 viral attacks starts by the interaction of spike protein (S Protein) to ACE2 receptor located at the cell surface of respiratory tract and digestive system cells, different endocrine targets, endocrine organs and metabolic conditions are of fundamental relevance for understanding disease progression and special outcomes, in particular those of fatal consequences for the patient. During pandemic, moreover, a specific phenotype of COVID-19 metabolic patient has been described, characterized by being at particular risk of worse outcomes. In the present paper we describe the mechanism of viral interaction with endocrine organs, emphasizing the specific endocrine molecules of particular relevance explaining COVID-19 disease evolution and outcomes.
Author(s): Berta Soldevila [sup.1], Manel Puig-Domingo [sup.1], Mónica Marazuela [sup.2] Author Affiliations: (1) grid.7080.f, 0000 0001 2296 0625, Endocrinology and Nutrition Service, Department of Medicine, Germans Trias i Pujol Research [...]