학술논문
Inhibition of Transforming Growth Factor-[beta] Production in Brain Pericytes Contributes to Cyclosporin A-Induced Dysfunction of the Blood-Brain Barrier
Document Type
Author abstract
Author
Source
Cellular and Molecular Neurobiology. May, 2007, Vol. 27 Issue 3, p317, 12 p.
Subject
Language
English
ISSN
0272-4340
Abstract
1. The present study was designed to clarify whether brain pericytes and pericyte-derived transforming growth factor-[beta]1 (TGF-[beta]1) participate in cyclosporin A (CsA)-induced dysfunction of the blood-brain barrier (BBB). 2. The presence of brain pericytes markedly aggravated CsA-increased permeability of MBEC4 cells to sodium fluorescein and accumulation of rhodamine 123 in MBEC4 cells. 3. Exposure to CsA significantly decreased the levels of TGF-[beta]1 mRNA in brain pericytes in pericyte co-cultures. Treatment with TGF-[beta]1 dose-dependently inhibited CsA-induced hyperpermeability and P-glycoprotein dysfunction of MBEC4 cells in pericyte co-cultures. 4. These findings suggest that an inhibition of brain pericyte-derived TGF-[beta]1 contributes to the occurrence of CsA-induced dysfunction of the BBB.