학술논문
Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38.sup.MAPK inhibitor RO3201195 for study in Werner syndrome cells
Document Type
Report
Author
Source
Bioorganic & Medicinal Chemistry Letters. July 1, 2008, Vol. 18 Issue 13, p3745, 4 p.
Subject
Language
English
ISSN
0960-894X
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.bmcl.2008.05.037 Byline: Mark C. Bagley (a), Terence Davis (b), Matthew C. Dix (a), Paola G.S. Murziani (a), Michal J. Rokicki (b), David Kipling (b) Keywords: p38 MAPK; Werner syndrome; RO3201195; Microwaves; Heterocycles Abstract: 5-Aminopyrazol-4-yl ketones can be prepared rapidly and efficiently using microwave heating for elaboration to the p38[alpha] MAP kinase inhibitor, RO3201195, which shows very high selectivity in Werner syndrome cells over JNK kinase. Author Affiliation: (a) School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff CF10 3AT, UK (b) Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK Article History: Received 6 March 2008; Revised 9 May 2008; Accepted 10 May 2008