학술논문
No association of MDM2 SNP309 with risk of glioblastoma and prognosis
Document Type
Report
Author abstract
Author abstract
Author
Source
Journal of Neuro-Oncology. Dec, 2007, Vol. 85 Issue 3, p241, 4 p.
Subject
Language
English
ISSN
0167-594X
Abstract
The MDM2 SNP309 variant has been shown to increase MDM2 expression and to be associated with tumor formation. In glioblastomas, the P53/MDM2 pathway is of crucial importance and MDM2 amplification is related to poor prognosis. However, we show here that MDM2 SNP309 is not associated with glioblastoma risk, and is not a prognostic factor.