학술논문
p-Tyrosol Enhances the Production of New Neurons in the Hippocampal CA1 Field after Transient Global Cerebral Ischemia in Rats
Document Type
Report
Author
Source
Bulletin of Experimental Biology and Medicine. December, 2019, Vol. 168 Issue 2, p224, 5 p.
Subject
Language
English
ISSN
0007-4888
Abstract
This study aimed at assessing the regenerative effect of p-tyrosol in transient global cerebral ischemia modeled in adult male Wistar rats by reversible occlusion of the three major vessels originating from the aortic arch and supplying the blood to the brain. p-Tyrosol was administered intraperitoneally in a dose of 20 mg/kg over 10 days after surgery. The death of Neu[N.sup.+] mature neurons and the number of newly formed [DCX.sup.+] neurons were assessed in the CA1 field of the hippocampus that is highly susceptible to damage in this model. We found that ischemia induced death of more than 50% mature neurons in the hippocampal CA1 field (p Key Words: neurogenesis; transient global cerebral ischemia; p-tyrosol; hippocampus; CA1 field
The process of formation of new neurons that occurs throughout the lifespan in specific neurogenic niches, the subventricular zone (SVZ) near the lateral ventricles and subgranular zone of the dentate [...]
The process of formation of new neurons that occurs throughout the lifespan in specific neurogenic niches, the subventricular zone (SVZ) near the lateral ventricles and subgranular zone of the dentate [...]