부산대학교 도서관

Experimental model of sulpiride-provoked benign prostatic hyperplasia was employed to comparatively assess the effect of phenolic antioxidants (dihydroquercetin, p-thyrozol, dibornol, and prostagenin) on prostate morphology. All examined agents decreased the degree of hyperplasia in acinar epithelium; the greatest efficacy was demonstrated by prostagenin. Moreover, dihydroquercetin and p-thyrozol increased the cross-section area of acinar lumina and prostate volume, which is inadmissible in this pathology. These results suggest that the use of phenolic antioxidants in the therapy of benign prostatic hyperplasia should be strictly controlled. Key Words: rats; benign prostatic hyperplasia; sulpiride; phenolic antioxidants
The prostate diseases belong to the most prevalent pathologies in men [6,14]. Benign prostatic hyperplasia (BPH) is typical of elderly patients. It is a multifactory disorder [4], and its pathogenesis [...]