학술논문
Presence of insulin-like growth factor I but absence of the binding proteins in the bile of rats
Document Type
Academic Journal
Author
Source
American Journal of Physiology (Consolidated). Jan 1995, Vol. 268 Issue 1, pR266, 6 p.
Subject
Language
ISSN
0002-9513
Abstract
Analysis of the bile from rats of different ages for the presence of insulin-like growth factor-1 (IGF-1) and the related binding proteins (IGFBPs) through Sephadex gel chromatography or Western ligand blot reveals that rat bile contains significant amounts of IGF-I and that IGFBPs are absent. Bile of suckling rats has a higher concentration of IGF-I than rat milk. Native IGF-I binding is suppressed in a dose dependent manner when bile samples are treated with a placental membrane IGF receptor preparation.