부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2007.05.039 Byline: Charlotte Laloux (a), Philippe Derambure (a), Jean-Marie Jacquesson (a), Regis Bordet (b), Alain Destee (c), Christelle Monaca (a) Keywords: MPTP mice; Dopamine; Paradoxical sleep; Parkinson's disease; Noradrenaline; Acetylcholine Abbreviations: 5-HT, serotonin; ACh, acetylcholine; DA, dopamine; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NA, noradrenaline; PD, Parkinson's disease; PS, paradoxical sleep; S/W, sleep/wakefulness; SWS, slow-wave sleep; GABA, gamma-amino butyric acid; i.p., intraperitoneal; TH, tyrosine hydroxylase Abstract: Sleep/wakefulness disorders are frequent in Parkinson's disease. Although the causes have yet to be established, it is known that dopaminergic neuronal lesions modulate paradoxical sleep (PS) regulation structures containing serotonin, noradrenaline and acetylcholine. Our previous vigilance state studies have revealed an increase in the amount of PS over the nyctohemeral period in the MPTP-treated mouse model of Parkinson's disease. The aim of the present work was to compare the effect of drugs modulating serotonin (citalopram), noradrenaline (desipramine), acetylcholine (arecoline) and dopamine (GBR 12909) neurotransmission on sleep/wakefulness patterns in MPTP mice and control mice. Citalopram reduced the amount of PS in MPTP and control mice to the same extent. Desipramine also induced a PS reduction, which was less pronounced in MPTP mice than in control mice. Arecoline increased the amount of PS in MPTP mice but not in controls. GBR 12909 induced a PS reduction (for the highest dose) more pronounced in MPTP mice than in control animals. Given that the responsiveness of MPTP mice differs markedly from that of controls, our study suggests that MPTP can alter sleep/wakefulness neurotransmission systems. Dysfunction of the latter may be responsible for PS disorders in MPTP mice. Author Affiliation: (a) Laboratoire de Physiologie, EA2683, Institut Federatif de Recherche 114, Faculte de Medecine Henri Warembourg, PA[acute accent]le recherche, 1 place de Verdun, F-59045 Lille cedex, France (b) Laboratoire de Pharmacologie, EA1046, Institut Federatif de Recherche 114, Faculte de Medecine, PA[acute accent]le recherche, F-59045 Lille cedex, France (c) Clinique Neurologique, EA2683, HA[acute accent]pital R. Salengro, CHRU de Lille, F-59037 Lille cedex, France Article History: Accepted 30 May 2007