부산대학교 도서관

It is counterintuitive that metabolic defects reducing ATP production can cause, rather than protect from, cancer. Yet this is precisely the case for familial paraganglioma, a form of neuroendocrine malignancy caused by loss of succinate dehydrogenase in the tricarboxylic acid cycle. Here we review biochemical, genetic, and epigenetic considerations in succinate dehydrogenase loss and present leading models and mysteries associated with this fascinating and important tumor.
1. Introduction: Overview of Glucose Metabolism Glucose metabolism is a central source of energy [1]. Glucose also provides metabolic intermediates for biosynthesis of nucleotides, fatty acids, amino acids, and coenzymes. [...]