학술논문
Formation of a copper specific binding site in non-native states of beta-2-microglobulin
Document Type
Academic Journal
Author
Source
Biochemistry. August 27, 2002, Vol. 41 Issue 34, p10646, 11 p.
Subject
Language
ISSN
0006-2960
Abstract
The binding of copper by non-native states of beta-2-microglobulin is facilitated by residues H13, H51, and H84. Data indicate that this copper binding destabilizes the protein and its subsequent incorporation into amyloid fiber leading to amyloidosis.