학술논문
IDENTIFICATION OF TWO GERMLINE POINT MUTATIONS IN THE 5'UTR OF THE ANDROGEN RECEPTOR GENE IN MEN WITH PROSTATE CANCER
Document Type
Academic Journal
Source
The Journal of Urology. Oct, 1997, Vol. 158 Issue 4, p1599, 3 p.
Subject
Language
English
ISSN
0022-5347
Abstract
As part of an ongoing study to identify germline mutations and/or polymorphisms in the androgen receptor (AR) gene which might be associated with prostate cancer, the 5'-untranslated region (5'UTR) of the AR gene was screened in genomic DNA of prostate cancer cases. This region, which is > 1kb in length, might modulate AR expression by affecting transcription and/or translation rates. A life-time exposure to enhanced AR expression, in turn, could potentially predispose to prostate cancer.