부산대학교 도서관

Objectives: The study aimed to determine whether there is a relationship between the age at diagnosis and the clinical, laboratory, and prognostic features in pediatric immunoglobulin A vasculitis (IgAV) patients. Patients and methods: In this study, 539 pediatric IgAV patients (298 males, 241 females; mean age: 7.74 [+ or -] 3.36 years; range, 1 to 17.8 years) were retrospectively evaluated between January 2005 and July 2020. The relationship between clinical findings and age at diagnosis was analyzed by univariate logistic regression analysis. Factors associated with renal involvement, steroid-dependent or refractory disease, and recurrence were examined. Results: The median age of diagnosis was 7.1 (1-17.8) years in all patients. At the time of admission, purpura, abdominal pain, and arthritis were the most common clinical findings. At the time of diagnosis, there was a positive association between age and purpura and an inverse association with the presence of arthritis. There were associations between renal involvement and age at diagnosis (odds ratio=1.22, 95% confidence interval 1.13-1.31, p Conclusion: Age at diagnosis and follow-up time may be associated with renal involvement and refractory and steroid-dependent disease in IgAV. In addition, there may be a relationship between steroid-dependent disease and renal, GI, and scrotal involvement and between GI involvement and recurrence. Keywords: Age at diagnosis, recurrence, refractory disease, steroid-dependent disease.
Immunoglobulin A vasculitis (IgAV) is a leukocytoclastic vasculitis affecting small vessels characterized by the accumulation of immunoglobulin A in the vessel wall. Nonthrombocytopenic purpura, abdominal pain, arthritis/arthralgia, and glomerulonephritis are [...]