학술논문
Total body irradiation + fludarabine compared to busulfan + fludarabine as 'reduced-toxicity conditioning' for patients with acute myeloid leukemia treated with allogeneic hematopoietic cell transplantation in first complete remission: a study by the Acute Leukemia Working Party of the EBMT
Document Type
Report
Author
Giebel, Sebastian; Labopin, Myriam; Sobczyk-Kruszelnicka, Malgorzata; Stelljes, Matthias; Byrne, Jenny L.; Fegueux, Nathalie; Beelen, Dietrich W.; Rovira, Montserrat; Spyridonidis, Alexandros; Blaise, Didier; Bornhauser, Martin; Karadogan, Ihsan; Savani, Bipin N.; Nagler, Arnon; Mohty, Mohamad; Martin, Sonja; Chevallier, Patrice
Source
Bone Marrow Transplantation. February, 2021, Vol. 56 Issue 2, p481, 11 p.
Subject
Language
English
ISSN
0268-3369
Abstract
The optimal conditioning for patients with acute myeloid leukemia in first complete remission treated with allogeneic hematopoietic cell transplantation (allo-HCT) has not been defined so far. In this retrospective study, we compared two "reduced-toxicity" regimens: intravenous busulfan at a total dose of 9.6 mg/kg (3 days) + fludarabine (Bu3/Flu) and total body irradiation at a dose of 8 Gy + fludarabine (TBI8Gy/Flu). In the entire study cohort (n = 518), the probabilities of overall survival (OS), leukemia-free survival (LFS), relapse and non-relapse mortality (NRM) at 2 years for Bu3/Flu and TBI8Gy/Flu were 62% vs. 72.5% (p = 0.051), 59.5% vs. 65% (p = 0.15), 30% vs. 20% (p = 0.01), and 10% vs. 14% (p = 0.18), respectively. In multivariate model for patients
Author(s): Sebastian Giebel [sup.1] , Myriam Labopin [sup.2] , Malgorzata Sobczyk-Kruszelnicka [sup.1] , Matthias Stelljes [sup.3] , Jenny L. Byrne [sup.4] , Nathalie Fegueux [sup.5] , Dietrich W. Beelen [sup.6] [...]
Author(s): Sebastian Giebel [sup.1] , Myriam Labopin [sup.2] , Malgorzata Sobczyk-Kruszelnicka [sup.1] , Matthias Stelljes [sup.3] , Jenny L. Byrne [sup.4] , Nathalie Fegueux [sup.5] , Dietrich W. Beelen [sup.6] [...]