부산대학교 도서관

Background: Recent studies indicated that dietary n-3 polyunsaturated fatty acids (PUFAs) increase circulating adiponectin concentrations in rodents. Objective: We aimed to investigate whether a diet rich in n-3 PUFAs increased plasma concentrations of total or high-molecular-weight (HMW) adiponectin in healthy overweight-to-moderately obese men and women. Design: Sixteen women and 10 men with a body mass index (in kg/[m.sup.2]) between 28 and 33 were randomly assigned to consume a diet rich in n-3 PUFAs (3.5% of energy intake) from both plant and marine sources or a control diet (0.5% of energy intake from n-3 PUFAs). For the first 2 wk, these diets were consumed under isocaloric conditions; then followed a 12-wk period of ad libitum consumption that was associated with a moderate loss of [approximately equal to] 3.5% of body weight in both groups. Total and HMW adiponectin plasma concentrations were measured before and after each diet phase. Results: Plasma fasting adiponectin concentrations did not change during the isocaloric period, but they increased modestly ([approximately equal to]10%) during the ad libitum period when subjects lost weight [P = 0.009 for time in repeated-measures analysis of variance] and to a similar extent in subjects consuming the control ([bar.x] [+ or -] SD: 0.42 [+ or -] 0.69 [micro]g/mL) and n-3 PUFA (0.45 [+ or -] 0.85 [micro]g/mL) diets (P = 0.920 for time x treatment interaction). Plasma concentrations of HMW adiponectin did not change significantly during the study. Conclusion: Dietary n-3 PUFAs consumed at levels of 3.5% of energy intake do not significantly increase plasma or HMW adiponectin concentrations in overweight-to-moderately obese healthy men and women over the course of 14 wk. KEY WORDS Adiponectin, fatty acids, omega-3, n-3, diet, obesity, overweight, humans