학술논문
Catalytic asymmetric rearrangement of [alpha],[alpha]-disubstituted [alpha]-siloxy aldehydes to optically active acyloins using axially chiral organoaluminum Lewis acids
Document Type
Academic Journal
Author
Source
Journal of the American Chemical Society. March 7, 2007, Vol. 129 Issue 9, p2410, 2 p.
Subject
Language
English
ISSN
0002-7863
Abstract
The development of skeletal rearrangement of [alpha],[alpha]-dialkyl-[alpha]-siloxy aldehydes to [alpha]-siloxy ketones, which is catalyzed by newly designed chiral organoaluminum Lewis acid with high enantioselectivity, is described. This has provided a unique tool for the synthesis of various acyloins and tertiary [alpha]-hydroxy aldehydes of high enantiomeric purities.