학술논문
Highly enantioselective conjugate addition of nitroalkanes to alkylidenemalonates using efficient phase-transfer catalysis of N-spiro chiral ammonium bromides
Document Type
Academic Journal
Author
Source
Journal of the American Chemical Society. Sept 29, 2004, Vol. 126 Issue 38, p11790, 2 p.
Subject
Language
English
ISSN
0002-7863
Abstract
The first highly enantioselective conjugate addition of nitoalkanes to alkylidenemalonates based on the utilization of efficient-phase transfer catalysis of appropriately designed chiral ammonium bromides is presented. This approach greatly expands the scope of the conjugate addition involving nitroalkanes as a donor substrate and provides a new and practical entry to optically active gamma-amino acid derivatives.