학술논문
Rate of thymidine analogue resistance mutation accumulation with Zidovudine- or stavudine-based regimens
Document Type
Academic Journal
Author
Source
Journal of Acquired Immune Deficiency Syndromes (1999). May 1, 2004, Vol. 36 Issue 1, p600, 4 p.
Subject
Language
English
ISSN
1525-4135
Abstract
The rate of thymidine analogue resistance mutations (TAMs) is determined by subjecting serial plasma samples from treatment-naive subjects, who were randomly assigned to receive Zidovudine (ZDV) and stavudine (d4T) in combination with lamivudine to genotype analysis of HIV-1. During the treatment with ZDV or d4T, it was observed that the TAMs may be accumulated at the same rates but the specific pattern of mutations may vary.