부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ejca.2005.12.015 Byline: J. Rudant (a), B. BaccaA[macron]ni (b), M. Ripert (a), A. Goubin (a), S. Bellec (a), D. Hemon (a), J. Clavel (a) Keywords: Childhood leukaemia; Population-mixing; Population density; Residence at the time of birth Abstract: The association between the risk of childhood leukaemia before age 7 years and population-mixing at the place of residence at birth was investigated by retrospectively considering all the children born in mainland French communes between 1st January 1990 and 31st December 1998. An increased risk of acute lymphoblastic leukaemia was found with higher levels of migration for children residing at birth in isolated communes with a population density [greater than or equal to]50 people per km.sup.2 (SIRR=2.59, 95% CI: 1.48-4.49). No association was observed with lower population densities. For children residing in non-isolated communes at birth, the results were similar but less marked. The risk tended to increase only for population densities [greater than or equal to]5000 people per km.sup.2 (SIRR=1.57, 95% CI: 0.99-2.52). The findings are consistent with epidemic models and support the hypothesis of an infectious aetiology relating to population-mixing. Population density may be seen as an indicator of the opportunity of contacts between inhabitants and should therefore be taken into account when investigating an infectious hypothesis. This is the first systematic study of population-mixing at the place of residence at the time of birth to be conducted on a national scale. Author Affiliation: (a) INSERM, U754, IFR69, Universite Paris-Sud XI - 16 Avenue Paul Vaillant Couturier, F-94807 Villejuif Cedex, France (b) INSEE Provence-Alpes-CA[acute accent]te d'Azur - 17, rue Menpenti, F-13 387 Marseille Cedex 10, France Article History: Received 23 September 2005; Revised 6 December 2005; Accepted 12 December 2005