학술논문
Efficacy and safety of conbercept as a primary treatment for choroidal neovascularization secondary to punctate inner choroidopathy
Document Type
Report
Author
Source
BMC Ophthalmology. June 12, 2017, Vol. 17 Issue 1
Subject
Language
English
ISSN
1471-2415
Abstract
Author(s): Yuting Peng[sup.1] , Xiongze Zhang[sup.1] , Lan Mi[sup.1] , Bing Liu[sup.1] , Chengguo Zuo[sup.1] , Miaoling Li[sup.1] and Feng Wen[sup.1] Background Choroidal neovascularization (CNV) is a disorder of the [...]
Background To evaluate the efficacy and safety of intravitreal conbercept (KH902) as the primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy. Methods This study was a retrospective, consecutive, observational case series. We reviewed medical records of 16 eyes (16 patients) with naive subfoveal or juxtafoveal choroidal neovascularization secondary to punctuate inner choroidopathy that were treated with intravitreal conbercept injections. All patients completed at least six months of follow-up. Best-corrected visual acuity (BCVA) was measured, and anatomical features were assessed with fluorescein angiography, indocyanine green angiography, and optical coherence tomography. Results At the month-6 follow-up visit, best-corrected visual acuity improved from 0.70 [+ or -] 0.36 (with approximate Snellen equivalent of 20/100) to 0.44 [+ or -] 0.25 (20/50 in Snellen) logarithm of the minimum angle of resolution (logMAR) (P = 0.003). Mean improvement of vision was 2.6 lines, with 50% treated eyes (8 eyes of 16) showing an improvement of [greater than or equai to]3 lines and 62.5% (10 eyes of 16), obtaining an improvement of [greater than or equai to]2 lines; all 16 eyes had stable or improved vision. Mean central retinal thickness decreased from 294.94 [+ or -] 102.68 [mu]m to 206.56 [+ or -] 61.71 [mu]m (P = 0.005). Fifteen eyes (93.75%) showed absence of CNV leakage at the end of the study period. No conbercrept-related systemic or ocular adverse events were observed. Conclusion Intravitreal injection of conbercept significantly improved visual and anatomical outcomes in choroidal neovascularization secondary to punctate inner choroidopathy over a 6-month follow-up period. Trial registration ISRCTN85678307, retrospectively registered on May 11, 2017. Keywords: Conbercept, KH902, Intravitreal injection, Choroidal neovascularization, Punctate inner choroidopathy, Efficacy
Background To evaluate the efficacy and safety of intravitreal conbercept (KH902) as the primary treatment of choroidal neovascularization secondary to punctate inner choroidopathy. Methods This study was a retrospective, consecutive, observational case series. We reviewed medical records of 16 eyes (16 patients) with naive subfoveal or juxtafoveal choroidal neovascularization secondary to punctuate inner choroidopathy that were treated with intravitreal conbercept injections. All patients completed at least six months of follow-up. Best-corrected visual acuity (BCVA) was measured, and anatomical features were assessed with fluorescein angiography, indocyanine green angiography, and optical coherence tomography. Results At the month-6 follow-up visit, best-corrected visual acuity improved from 0.70 [+ or -] 0.36 (with approximate Snellen equivalent of 20/100) to 0.44 [+ or -] 0.25 (20/50 in Snellen) logarithm of the minimum angle of resolution (logMAR) (P = 0.003). Mean improvement of vision was 2.6 lines, with 50% treated eyes (8 eyes of 16) showing an improvement of [greater than or equai to]3 lines and 62.5% (10 eyes of 16), obtaining an improvement of [greater than or equai to]2 lines; all 16 eyes had stable or improved vision. Mean central retinal thickness decreased from 294.94 [+ or -] 102.68 [mu]m to 206.56 [+ or -] 61.71 [mu]m (P = 0.005). Fifteen eyes (93.75%) showed absence of CNV leakage at the end of the study period. No conbercrept-related systemic or ocular adverse events were observed. Conclusion Intravitreal injection of conbercept significantly improved visual and anatomical outcomes in choroidal neovascularization secondary to punctate inner choroidopathy over a 6-month follow-up period. Trial registration ISRCTN85678307, retrospectively registered on May 11, 2017. Keywords: Conbercept, KH902, Intravitreal injection, Choroidal neovascularization, Punctate inner choroidopathy, Efficacy