부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jhin.2007.08.010 Byline: P. MuA[+ or -]oz (a), J. Hortal (b), M. Giannella (a), J.M. Barrio (b), M. Rodriguez-Creixems (a), M.J. Perez (b), C. Rincon (b), E. Bouza (a) Abstract: Staphylococcus aureus is the main cause of surgical site infection (SSI) after major heart surgery (MHS), with the patient's endogenous flora as the principal source. However, the influence of nasal carriage of S. aureus on the development of SSI after MHS has not been established and Centers for Disease Control and Prevention guidelines do not make a recommendation for or against decolonisation. We performed a one-year observational study in which patients undergoing MHS were screened for nasal carriage of S. aureus before surgery. Cases of SSI were recorded and the risk factors of patients with and without SSI were analysed. During the study period, 357 patients were included in the protocol. Ninety-six patients (27%) were found to be nasal carriers of S. aureus and nine (9.4%) of these had meticillin-resistant (MRSA) strains. The overall incidence of SSI was 6.4%, with 4.2% for mediastinitis and 2.2% for superficial SSI. Nasal carriers of S. aureus had a significantly higher incidence of SSI than non-carriers (12.5% vs 5%, P =0.01). Among MRSA carriers, the incidence of SSI reached 33% (P Author Affiliation: (a) Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario 'Gregorio MaraA[+ or -]on', Universidad Complutense, Madrid, Spain and Centro Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES) (b) Anesthesiology Department, Hospital General Universitario 'Gregorio MaraA[+ or -]on', Universidad Complutense, Madrid, Spain Article History: Received 15 February 2007; Accepted 3 August 2007