학술논문

Targeting ischemic memory
Document Type
Author abstract
Source
Current Opinion in Biotechnology. Feb, 2007, Vol. 18 Issue 1, p46, 6 p.
Subject
Language
English
ISSN
0958-1669
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.copbio.2006.11.002 Byline: Omer Aras, Vasken Dilsizian Abstract: Long-chain free fatty acids and glucose account for the vast majority of ATP production in the heart. An alteration of fatty acid oxidation is considered to be a sensitive marker of ischemia and myocardial damage. Recently, several radiolabeled fatty acid analogs have been introduced to assess myocardial cellular function. The use of such analogs has enabled the analysis of cardiac metabolism and led to the identification of prior ischemic events, termed 'ischemic memory'. Such advances will find use in the clinical setting for the diagnosis and treatment of subclinical or progressive cardiovascular disorders, as in acute coronary syndrome, that often remain elusive with traditional imaging approaches. Author Affiliation: Division of Nuclear Medicine, The University of Maryland Hospital and School of Medicine, 22 South Greene Street, Room N2W78, Baltimore, Maryland 21201-1595, USA