학술논문
Rhodococcus induced false-positive galactomannan (GM), a biomarker of fungal presentation, in patients with peritoneal dialysis: case reports
Document Type
Academic Journal
Author
Source
BMC Nephrology. December 2, 2019, Vol. 20 Issue 1
Subject
Language
English
ISSN
1471-2369
Abstract
Author(s): Tamonwan Chamroensakchai[sup.1,2], Wasin Manuprasert[sup.2], Asada Leelahavanichkul[sup.1], Kullaya Takkavatakarn[sup.3], Nisa Thongbor[sup.4], Bunpring Jaroenpattrawut[sup.5] and Talerngsak Kanjanabuch[sup.2,3,6] Background Fungal peritonitis is a relatively uncommon but serious complication of peritoneal dialysis (PD) [...]
Background Galactomannan index (GMI) at a level higher than 0.5 provides high sensitivity and specificity for the diagnosis of fungal peritonitis. Here, we report the false-positive of GMI in peritoneal dialysis (PD) effluent (PDE) due to Rhodococcus peritonitis in PD patients. Case presentation GMI in PDE of case #1 and case #2 were 1.53 and 0.76, respectively, while serum GMI of both cases was less than 0.5. In addition, GMI from the specimens obtained directly from the stationary phase of Rhodococcus colonies were 1.27 and 1.56, which were isolated from case #1 and #2, accordingly. Conclusion High GMI in PDE of PD patients is not specific just for fungal infections but may also be secondary to other infections, such as Rhodococcus spp., especially in endemic areas.
Background Galactomannan index (GMI) at a level higher than 0.5 provides high sensitivity and specificity for the diagnosis of fungal peritonitis. Here, we report the false-positive of GMI in peritoneal dialysis (PD) effluent (PDE) due to Rhodococcus peritonitis in PD patients. Case presentation GMI in PDE of case #1 and case #2 were 1.53 and 0.76, respectively, while serum GMI of both cases was less than 0.5. In addition, GMI from the specimens obtained directly from the stationary phase of Rhodococcus colonies were 1.27 and 1.56, which were isolated from case #1 and #2, accordingly. Conclusion High GMI in PDE of PD patients is not specific just for fungal infections but may also be secondary to other infections, such as Rhodococcus spp., especially in endemic areas.