부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.exppara.2007.05.006 Byline: Workineh Torben (a), Asrat Hailu (b) Keywords: Cercopithecus aethiops aethiops; 20 Krad irradiated cercaria vaccine; Granuloma; Worm load; Egg loads Abstract: The absence of appropriate animal models is a challenge for those designing anti-schistosome vaccines. In order to observe the development of hepatic granulomata, 20 Krad irradiated cercaria vaccinated grivet monkeys (Cercopithecus aethiops aethiops) were experimentally infected with Schistosoma mansoni. Most human clinical manifestations of schistosomiasis were noted in the infected monkeys. Intraperitonial immunization with 20 Krad irradiated cercaria resulted in a relatively less granulomatous reaction and lower egg mass (P Author Affiliation: (a) Aklilu Lemma Institute of Pathobiology, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia (b) Medical Faculty, Department of Microbiology, Parasitology & Immunology, Addis Ababa University, P.O. Box 9086, Addis Ababa, Ethiopia Article History: Received 7 December 2006; Revised 30 April 2007; Accepted 4 May 2007