부산대학교 도서관

The standard operation for colitic cancer in ulcerative colitis (UC) is restorative proctocolectomy; however, sporadic colorectal cancer (CRC) can coincidentally arise in patients with UC and the optimal procedure remains controversial. Therefore, it is crucial to preoperatively determine whether the CRC in UC is a sporadic or colitic cancer. We report a case of avoiding proctocolectomy for sporadic CRC in a patient with UC based on preoperative diagnosis involving p53 immunostaining. A 73-year-old man with CRC in UC had undergone sigmoid colectomy with lymphadenectomy because of the submucosal deep invasion pathologically after endoscopic mucosal resection. The cancer was diagnosed sporadic cancer preoperatively not only based on the endoscopic, clinical, and histological patterns but also that the colon epithelium was unlikely to develop dysplasia as the circumference and unaffected UC mucosa did not detect p53 protein overexpression. Recent reports have shown that the immunohistochemical detection of p53 protein overexpression can be useful for a differential diagnosis and as a predictor of dysplasia and colitic cancer. The analysis of p53 mutation status based on immunostaining of p53 protein expression in the unaffected UC mucosa can be useful for the decision regarding a surgical procedure for CRC in patients with UC. Keywords: Sporadic cancer, Ulcerative colitis, p53 overexpression
Author(s): Haruki Sada[sup.1] , Manabu Shimomura[sup.1] , Takao Hinoi[sup.1] , Hiroyuki Egi[sup.1] , Koji Kawaguchi[sup.1] , Takuya Yano[sup.1] , Hiroaki Niitsu[sup.1] , Yasufumi Saitou[sup.1] , Hiroyuki Sawada[sup.1] , Masashi Miguchi[sup.1] [...]