학술논문
The insulin receptor C-terminus is involved in regulation of the receptor kinase activity
Document Type
Academic Journal
Author
Source
Biochemistry. Sept 21, 1993, Vol. 32 Issue 37, p9539, 6 p. photograph
Subject
Language
ISSN
0006-2960
Abstract
Receptor kinase activity is affected by the complete C-terminus seen in the insulin receptor beta-subunit. The area between the kinase region and the C-terminal region exhibits bidirectional interplay which depends on structural modifications. The three kinase area tyrosine sites are subjected to phosphorylation, which does not influence the structural modification in the C-terminal, to induce receptor activity. The enzyme activity is alternately encouraged or prevented by the changes in the receptor kinase caused by disturbances in the C-terminal area.