부산대학교 도서관

Brain metastases occur in 1% of sarcoma cases and are associated with a median overall survival of 6 months. We report a rare case of a brain metastasis with unique radiologic and histopathologic features in a patient with low grade fibromyxoid sarcoma (LGFMS) previously treated with immune checkpoint inhibitor (ICI) therapy. The lone metastasis progressed in the midbrain tegmentum over 15 months as a non-enhancing, T2-hyperintense lesion with peripheral diffusion restriction, mimicking a demyelinating lesion. Histopathology of the lesion at autopsy revealed a rich infiltrate of tumor-associated macrophages (TAMs) with highest density at the leading edge of the metastasis, whereas there was a paucity of lymphocytes, suggestive of an immunologically cold environment. Given the important immunosuppressive and tumor-promoting functions of TAMs in gliomas and carcinoma/melanoma brain metastases, this unusual case provides an interesting example of a dense TAM infiltrate in a much rarer sarcoma brain metastasis. Keywords: Sarcoma, Brain metastasis, Tumor-associated macrophages, Brain tumor microenvironment
Author(s): David Rogawski[sup.1], Joshua Wheeler[sup.2], Esther Nie[sup.3], William Zhu[sup.4], Eleanor Villanueva[sup.1], Gwen Coffey[sup.1], Qian Ma[sup.4], Kristen Ganjoo[sup.5], Nancy Fischbein[sup.6], Michael Iv[sup.6], Hannes Vogel[sup.2] and Seema Nagpal[sup.1] Introduction The development of [...]