학술논문
Correlation of clinical severity and ELISA indices for the NC16A domain of BP180 measured using BP180 ELISA kit in bullous pemphigoid
Document Type
Academic Journal
Author
Source
Journal of Dermatological Science. March, 2005, Vol. 37 Issue 3, p145, 5 p.
Subject
Language
English
ISSN
0923-1811
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jdermsci.2004.10.007 Byline: Yukiko Tsuji-Abe, Masashi Akiyama, Yasuko Yamanaka, Toshiro Kikuchi, Kazuko C. Sato-Matsumura, Hiroshi Shimizu Keywords: Autoantibody; BP; BPAG2; Indirect immunofluorescence; Steroid resistant Abstract: Titres of circulating autoantibodies detected by indirect immunofluorescence (IIF) have been used for the diagnosis and evaluation of disease activity in bullous pemphigoid (BP). In BP, the major pathogenic epitope is known to be the non-collagenous extracellular domain (NC16A) of the 180-kDa transmembrane hemidesmosomal protein (BPAG2). Recently, an enzyme-linked immunosorbent assay (ELISA) kit using the NC16A domain recombinant protein (BP180 ELISA kit) has become commercially available to measure the quantities of pathogenic autoantibodies circulating in BP patients. Author Affiliation: Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo 060-8638, Japan Article History: Received 8 September 2004; Revised 25 October 2004; Accepted 27 October 2004