학술논문
Osteopontin Expression in Vascular Smooth Muscle Cells in Patients With End-Stage Renal Disease
Document Type
Author abstract
Author
Source
Therapeutic Apheresis and Dialysis. June, 2006, Vol. 10 Issue 3, p273, 5 p.
Subject
Language
English
ISSN
1744-9979
Abstract
To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1744-9987.2006.00376.x Byline: Hironori Nakamura (1), Hirokazu Honda (1), Yoshifumi Inada (2), Noriyuki Kato (1), Kenichi Kato (1), Kozo Kitazawa (1), Tetsuzo Sugisaki (1) Keywords: Blood Urea Nitrogen; Osteopontin; Phosphorus; Renal Failure; Vascular Smooth Muscle Cells Abstract: Abstract: [beta]-glycerophosphate, a phosphate donor, and uremic sera induce osteopontin (OPN) expression in bovine vascular smooth muscle cells (VSMCs). However, the correlations of serum phosphorus level with OPN expression, and blood urea nitrogen (BUN) level with OPN expression in humans have not previously been reported. The purpose of the current study is to compare the expression of OPN in VSMCs with clinical data in patients with end-stage renal disease (ESRD). The radial arteries of 33 patients (21 male and 12 female patients) were examined to determine the expression of OPN and collagen type I (Col I) by immunohistochemistry. The correlation of the expression of bone matrix proteins with clinical data was analyzed. Between the low-serum phosphorus ( Author Affiliation: (1)Department of Nephrology, Showa University School of Medicine, Tokyo, and (2)Department of Internal Medicine, Kanto Rosai Hospital, Kawasaki, Kanagawa, Japan Article History: Received June 2005; revised November 2005. Article note: Dr Hironori Nakamura, Department of Nephrology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan. Email: h-mon@east.cts.ne.jp