학술논문
Clinical and survival differences during separate COVID-19 surges: Investigating the impact of the Sars-CoV-2 alpha variant in critical care patients
Document Type
Report
Author
Source
PLoS ONE. July 1, 2022, Vol. 17 Issue 7, e0269244
Subject
Language
English
ISSN
1932-6203
Abstract
A number of studies have highlighted physiological data from the first surge in critically unwell Covid-19 patients but there is a paucity of data describing emerging variants of SARS-CoV-2, such as B.1.1.7. We compared ventilatory parameters, biochemical and physiological data and mortality between the first and second COVID-19 surges in the United Kingdom, where distinct variants of SARS-CoV-2 were the dominant stain. We performed a retrospective cohort study investigating critically unwell patients admitted with COVID-19 across three tertiary regional ICUs in London, UK. Of 1782 adult ICU patients screened, 330 intubated and ventilated patients diagnosed with COVID-19 were included. In the second wave where B.1.1.7 variant was the dominant strain, patients were had increased severity of ARDS whilst compliance was greater (p
Author(s): Andrew I. Ritchie 1,2, Owais Kadwani 2, Dina Saleh 2, Behrad Baharlo 2, Lesley R. Broomhead 2, Paul Randell 2, Umeer Waheed 2, Maie Templeton 2, Elizabeth Brown 2, [...]
Author(s): Andrew I. Ritchie 1,2, Owais Kadwani 2, Dina Saleh 2, Behrad Baharlo 2, Lesley R. Broomhead 2, Paul Randell 2, Umeer Waheed 2, Maie Templeton 2, Elizabeth Brown 2, [...]