부산대학교 도서관

Introduction Immune checkpoints refer to inhibitory pathways that are crucial for maintaining self-tolerance and modulating physiological immune responses [1]. Tumor cells adapt the same pathways to avoid immune detection and [...]
The development of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of patients with advanced stage cancers. However, immune-related adverse events are frequently observed. Cardiac toxicity from ICI therapy can range from asymptomatic troponin-I elevations to conduction abnormalities of the heart and even fulminant myocarditis. Although rare, myocarditis is a potentially fatal adverse effect of ICI therapy. We present a series of five cases of ICI-related cardio-toxicity diagnosed and managed at Roswell Park Comprehensive Cancer Center along with a review of published case reports in the literature. Our series highlights the importance of high clinical suspicion, early diagnosis of myocarditis, and prompt initiation of immunosuppressive therapy. Keywords Cardiotoxicity * Immune checkpoint inhibitors * Myocarditis * Autoimmune * Cardio-oncology