학술논문
Transgenerational disruption of functional 5-HT.sub.1AR-induced connectivity in the adult mouse brain by traumatic stress in early life
Document Type
Report
Author
Source
Molecular Psychiatry. April 2017, Vol. 22 Issue 4, p519, 8 p.
Subject
Language
English
ISSN
1359-4184
Abstract
Author(s): F Razoux [sup.1] [sup.2] , H Russig [sup.1] , T Mueggler [sup.2] [sup.4] , C Baltes [sup.2] , K Dikaiou [sup.2] , M Rudin [sup.2] [sup.3] , I M [...]
Traumatic stress in early life is a strong risk factor for psychiatric disorders that can affect individuals across several generations. Although the underlying mechanisms have been proposed to implicate serotonergic transmission in the brain, the neural circuits involved remain poorly delineated. Using pharmacological functional magnetic resonance imaging in mice, we demonstrate that traumatic stress in postnatal life alters 5-HT.sub.1A receptor-evoked local and global functions in both, the exposed animals and their progeny when adult. Disrupted functional connectivity is consistent across generations and match limbic circuits implicated in mood disorders, but also networks not previously linked to traumatic stress. These findings underscore the neurobiology and functional mapping of transgenerational effects of early life experiences.
Traumatic stress in early life is a strong risk factor for psychiatric disorders that can affect individuals across several generations. Although the underlying mechanisms have been proposed to implicate serotonergic transmission in the brain, the neural circuits involved remain poorly delineated. Using pharmacological functional magnetic resonance imaging in mice, we demonstrate that traumatic stress in postnatal life alters 5-HT.sub.1A receptor-evoked local and global functions in both, the exposed animals and their progeny when adult. Disrupted functional connectivity is consistent across generations and match limbic circuits implicated in mood disorders, but also networks not previously linked to traumatic stress. These findings underscore the neurobiology and functional mapping of transgenerational effects of early life experiences.