부산대학교 도서관

OBJECTIVE: The objective of our study was to determine the feasibility and safety of enoxaparin whole milligram dosing in premature and term neonates, and to assess response to treatment. STUDY DESIGN: Retrospective study of neonates with thrombosis treated between January 2008 and December 2014. RESULT: Nineteen premature and 21 term neonates were treated with whole milligram doses of enoxaparin. The mean starting and therapeutic enoxaparin doses were 1.72 [+ or -] 0.17 and 1.86 [+ or -] 0.17 mg [kg.sup.-1], respectively. Twenty-five (64%) reached therapeutic antifactor Xa (anti-Xa) levels with the starting dose, whereas 14 (36%) required dose adjustments. One neonate reached a supratherapeutic anti-Xa level (>1.0IU [ml.sup.-1]) in the loading phase. No bleeding episodes occurred. The mean treatment duration was 12 weeks. Among 34 (85%) evaluable patients, 23 (68%) had a complete response, 9 (26%) partial and 2 (6%) had a stable thrombotic state. CONCLUSION: Whole milligram dosing of enoxaparin for thrombosis is feasible, safe and effective in premature and term neonates. Journal of Perinatology (2015) 35, 852-854; doi: 10.1038/jp.2015.84; published online 16 July 2015
INTRODUCTION The incidence of thrombosis peaks in the neonatal period because of a hypercoagulable state conferred by the developing coagulation system, comorbidities such as congenital heart disease and the need [...]