부산대학교 도서관

Background We compared clinical outcomes among HIV-infected participants receiving ART who were randomized to viral load (VL) and CD4 cell count monitoring in comparison to CD4 cell count monitoring alone in Tororo, Uganda. Methods Beginning in May 2003, participants with CD4 cell counts Results We randomized 1211 participants to the three original study arms and 331 surviving participants in the clinical monitoring arm were re-randomized to the CD4-VL and CD4 only arms. At enrolment the median age was 38 years and the median CD4 cell count was 134 cells/[mu]L. Over a median of 5.2 years of follow-up, 37 deaths and 35 new OIs occurred in the VL-CD4 arm patients, 39 deaths and 42 new OIs occurred in CD4-only patients. We did not observe an association between monitoring arm and new OIs or death (AHR =1.19 for CD4-only vs. CD4-VL; 95 % CI 0.82-1.73). Conclusion We found no differences in clinical outcomes associated with the addition of quarterly VL monitoring to quarterly CD4 cell count monitoring. Keywords: Antiretroviral therapy, Virologic failure, Morbidity, Mortality, Sub-Saharan Africa, Uganda
Author(s): Stephen Okoboi[sup.1] , Paul John Ekwaru[sup.2] , James D. Campbell[sup.3] , Aggrey Egessa[sup.1] , Racheal King[sup.4] , Celestin Bakanda[sup.1] , Emmy Muramuzi[sup.5] , Frank Kaharuza[sup.5] , Samuel Malamba[sup.5] and [...]