학술논문
Comprehensive analysis of drugs to treat SARS-CoV-2 infection: Mechanistic insights into current COVID-19 therapies (Review)
Document Type
Academic Journal
Author
Source
International Journal of Molecular Medicine. August 2020, Vol. 46 Issue 2, p467, 22 p.
Subject
Language
English
ISSN
1107-3756
Abstract
1. Introduction The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), provisionally named as 2019-ncoV and colloquially known as the coronavirus, is the pandemic-causing pathogen behind coronavirus disease 2019 (COVID-19), which [...]
The major impact produced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) focused many researchers attention to find treatments that can suppress transmission or ameliorate the disease. despite the very fast and large flow of scientific data on possible treatment solutions, none have yet demonstrated unequivocal clinical utility against coronavirus disease 2019 (COVID-19). This work represents an exhaustive and critical review of all available data on potential treatments for COVID-19, highlighting their mechanistic characteristics and the strategy development rationale. Drug repurposing, also known as drug repositioning, and target based methods are the most used strategies to advance therapeutic solutions into clinical practice. current in silico, in vitro and in vivo evidence regarding proposed treatments are summarized providing strong support for future research efforts. Contents 1. Introduction 2. Virological, genomic, and host aspects related to COVID-19 treatment 3. Pathogenesis 4. Treatment strategies 5. discussion
The major impact produced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) focused many researchers attention to find treatments that can suppress transmission or ameliorate the disease. despite the very fast and large flow of scientific data on possible treatment solutions, none have yet demonstrated unequivocal clinical utility against coronavirus disease 2019 (COVID-19). This work represents an exhaustive and critical review of all available data on potential treatments for COVID-19, highlighting their mechanistic characteristics and the strategy development rationale. Drug repurposing, also known as drug repositioning, and target based methods are the most used strategies to advance therapeutic solutions into clinical practice. current in silico, in vitro and in vivo evidence regarding proposed treatments are summarized providing strong support for future research efforts. Contents 1. Introduction 2. Virological, genomic, and host aspects related to COVID-19 treatment 3. Pathogenesis 4. Treatment strategies 5. discussion