학술논문
P. falciparum Invasion and Erythrocyte Aging
Document Type
Academic Journal
Author
Source
Cells. February 2024, Vol. 13 Issue 4
Subject
Language
English
ISSN
2073-4409
Abstract
Author(s): María Fernanda Alves-Rosa; Nicole M. Tayler [†]; Doriana Dorta; Lorena M. Coronado; Carmenza Spadafora (corresponding author) [*] 1. Introduction: The Malaria Burden After more than 120 years of research, [...]
Plasmodium parasites need to find red blood cells (RBCs) that, on the one hand, expose receptors for the pathogen ligands and, on the other hand, maintain the right geometry to facilitate merozoite attachment and entry into the red blood cell. Both characteristics change with the maturation of erythrocytes. Some Plasmodia prefer younger vs. older erythrocytes. How does the life evolution of the RBC affect the invasion of the parasite? What happens when the RBC ages? In this review, we present what is known up until now.
Plasmodium parasites need to find red blood cells (RBCs) that, on the one hand, expose receptors for the pathogen ligands and, on the other hand, maintain the right geometry to facilitate merozoite attachment and entry into the red blood cell. Both characteristics change with the maturation of erythrocytes. Some Plasmodia prefer younger vs. older erythrocytes. How does the life evolution of the RBC affect the invasion of the parasite? What happens when the RBC ages? In this review, we present what is known up until now.