부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.actbio.2008.11.032 Byline: H.B. Pan (a)(b), Z.Y. Li (a), W.M. Lam (a), J.C. Wong (a), B.W. Darvell (b), K.D.K. Luk (a), W.W. Lu (a) Keywords: Solid titration; Solubility; Strontium-substituted apatite; Hydroxyapatite Abstract: Solid titration was used to explore the solubility isotherms of partially (Srx-HAp, x =1, 5, 10, 40, 60mol.%) and fully substituted strontium hydroxyapatite (Sr-HAp). Solubility increased with increasing strontium content. No phase other than strontium-substituted HAp, corresponding to the original titrant, was detected in the solid present at equilibrium; in particular, dicalcium hydrogen phosphate was not detected at low pH. The increase in solubility with strontium content is interpreted as a destabilization of the crystal structure by the larger strontium ion. Carbonated HAp was formed in simulated body fluid containing carbonate on seeding with Sr10-HAp, but the precipitate was strontium-substituted on seeding with Sr-HAp. Strontium-substituted HAp might be usable as a template for the growth of new bone, since nucleation appears to be facilitated. Author Affiliation: (a) Department of Orthopaedics & Traumatology, The University of Hong Kong, Kowloon, Hong Kong (b) Dental Materials Science Unit, The University of Hong Kong, Hong Kong Article History: Received 26 July 2008; Revised 10 October 2008; Accepted 25 November 2008