부산대학교 도서관

Backgrounds The prognostic implication of weight loss after discharge from acute heart failure (AHF) remains unclear. We sought to investigate the association of weight loss between discharge and 6-month visit with subsequent clinical outcomes in patients with AHF. Methods We analyzed 686 patients with AHF in the prospective longitudinal follow-up study derived from the Kyoto Congestive Heart Failure registry, and divided them into 2 groups based on the weight loss at 6-month index visit. We defined the weight loss as [greater than or equal to] 5% decrease in body weight from discharge to 6-month index visit. Results There were 90 patients (13.1%) with a weight loss at 6-month visit. Patients in the weight loss group compared with those in the no weight loss group had higher body weight at discharge and lower body weight at 6-mont visit. Patients in the weight loss group had a lower systolic blood pressure, higher brain-type natriuretic peptide, lower serum albumin, lower hemoglobin, higher prevalence of heart failure with reduced ejection fraction at 6-month visit, and a lower prescription rate of inhibitors of renin-angiotensin system than those in the no weight loss group. The cumulative 6-month incidence of all-cause death was significantly higher in the weight loss group than in the no weight loss group (14.2% and 4.3%, log-rank P Conclusion Body weight loss of [greater than or equal to]5% at 6-month visit after discharge was associated with subsequent all-cause death in patients with AHF.
Author(s): Yuta Seko 1, Takao Kato 1,*, Takeshi Morimoto 2, Hidenori Yaku 1, Yasutaka Inuzuka 3, Yodo Tamaki 4, Neiko Ozasa 1, Masayuki Shiba 1, Erika Yamamoto 1, Yusuke Yoshikawa [...]