학술논문
Advances in the Applications of Extracellular Vesicle for the Treatment of Skin Photoaging: A Comprehensive Review
Document Type
Academic Journal
Author
Source
International Journal of Nanomedicine. November 30, 2023, Vol. 18, p6411, 13 p.
Subject
Language
English
ISSN
1178-2013
Abstract
Introduction Skin, being the largest barrier organ, is susceptible to various injuries caused by genetic factors, lifestyle choices, nutrition, solar radiation, and environmental factors. (1-3) Skin aging and diseases impose [...]
Skin photoaging is a complex biological process characterized by the accumulation of oxidative damage and structural changes in the skin, resulting from chronic exposure to ultraviolet (UV) radiation. Despite the growing demand for effective treatments, current therapeutic options for skin photoaging remain limited. However, emerging research has highlighted the potential of extracellular vesicles (EVs), including exosomes, micro-vesicles, apoptotic bodies and liposomes, as promising therapeutic agents in skin rejuvenation. EVs are involved in intercellular communication and can deliver bioactive molecules, including proteins, nucleic acids, and lipids, to recipient cells, thereby influencing various cellular processes. This comprehensive review aims to summarize the current research progress in the application of EVs for the treatment of skin photoaging, including their isolation and characterization methods, roles in skin homeostasis, therapeutic potential and clinical applications for skin photoaging. Additionally, challenges and future directions in EVs-based therapies for skin rejuvenation are discussed. Keywords: extracellular vesicles, exosomes, liposomes, stem cells, skin photoaging, skin rejuvenation
Skin photoaging is a complex biological process characterized by the accumulation of oxidative damage and structural changes in the skin, resulting from chronic exposure to ultraviolet (UV) radiation. Despite the growing demand for effective treatments, current therapeutic options for skin photoaging remain limited. However, emerging research has highlighted the potential of extracellular vesicles (EVs), including exosomes, micro-vesicles, apoptotic bodies and liposomes, as promising therapeutic agents in skin rejuvenation. EVs are involved in intercellular communication and can deliver bioactive molecules, including proteins, nucleic acids, and lipids, to recipient cells, thereby influencing various cellular processes. This comprehensive review aims to summarize the current research progress in the application of EVs for the treatment of skin photoaging, including their isolation and characterization methods, roles in skin homeostasis, therapeutic potential and clinical applications for skin photoaging. Additionally, challenges and future directions in EVs-based therapies for skin rejuvenation are discussed. Keywords: extracellular vesicles, exosomes, liposomes, stem cells, skin photoaging, skin rejuvenation