학술논문
Very stable ribonucleotide substrate radical relevant for class I ribonucleotide reductase
Document Type
Academic Journal
Author
Source
Journal of Physical Chemistry B. August 10, 2000, Vol. 104 Issue 31, 7502-7509
Subject
Language
English
ISSN
1520-6106
Abstract
The radical E441Q mutant of ribonucleotide reductase, a new substrate radical that was discovered on the minute time scale, the nature of which is studied using density functional calculations is reported. The findings reveal that a very stable substrate radical was observed, which lies outside the normal substrate pathway, and is so stable that its creation has to be avoided by the enzyme, or the substrate reactions would be slowed by several orders of magnitude.