학술논문
The Relationship Between Vitamin D Gene Polymorphisms and the Diagnosis of Prostate Cancer in Patients with High Prostate-Specific Antigen Value
Original Article
Original Article
Document Type
Report
Author
Source
Bulletin of Urooncology. December 2020, Vol. 19 Issue 4, p191, 5 p.
Subject
Language
English
Abstract
Introduction Globally, prostate cancer (PCa) is the 2(nd) most common cancer (13%) and 5(th) most common lethal malignancy (6.7%) in men per the GLOBOCAN data (1). Its etiology is multifactorial [...]
Objective: To investigate the effects of vitamin D levels and vitamin D receptor (VDR) Bsml, Fokl, Taql, and Apal gene polymorphisms on prostate cancer (PCa) diagnosis in Turkish men with high prostate-specific antigen (PSA) levels during screening. Materials and Methods: Patients who were admitted to the outpatient clinic with elevated PSA levels and were scheduled for transrectal prostate biopsy were included. Patients diagnosed with PCa were divided into two groups of either localized disease (low/intermediate/high risk) or metastatic disease for subgroup analysis. The control group comprised patients whose biopsies revealed benign pathologies. Blood samples were collected from each patient after 12 hours of fasting before the prostate biopsy. Vitamin D levels and VDR gene polymorphisms were determined by ECLIA method and restriction fragment length polymorphism analysis, respectively. Results: A total of 77 patients (PCa, 39; benign, 38) were included in the study. The frequencies of Bsml, Fokl, Taql, and Apal genotypes for PCa and benign groups were evaluated. Vitamin D deficiency was detected in 88.6% and 94.9% of the benign and PCa groups, respectively (p=0.176). The Fokl Ff and Bsml bb genotypes, and Fokl FF and Bsml Bb genotypes were found to be more common in the PCa and benign groups, respectively. Apal Aa and Taql Tt were found to be more frequent in both groups. In patients with metastatic PCa; Bsml Bb genotype, Apal Aa genotype, and Taql Tt genotypes were found to be more common. Conclusion: Although Bsml Bb genotype, Apal Aa genotype, and Taql Tt genotypes were more commonly found in patients with metastatic PCa, further studies with increased sample sizes are needed to support this relationship in the Turkish PCa population. Keywords: Prostate cancer, vitamin D, gene polymorphism
Objective: To investigate the effects of vitamin D levels and vitamin D receptor (VDR) Bsml, Fokl, Taql, and Apal gene polymorphisms on prostate cancer (PCa) diagnosis in Turkish men with high prostate-specific antigen (PSA) levels during screening. Materials and Methods: Patients who were admitted to the outpatient clinic with elevated PSA levels and were scheduled for transrectal prostate biopsy were included. Patients diagnosed with PCa were divided into two groups of either localized disease (low/intermediate/high risk) or metastatic disease for subgroup analysis. The control group comprised patients whose biopsies revealed benign pathologies. Blood samples were collected from each patient after 12 hours of fasting before the prostate biopsy. Vitamin D levels and VDR gene polymorphisms were determined by ECLIA method and restriction fragment length polymorphism analysis, respectively. Results: A total of 77 patients (PCa, 39; benign, 38) were included in the study. The frequencies of Bsml, Fokl, Taql, and Apal genotypes for PCa and benign groups were evaluated. Vitamin D deficiency was detected in 88.6% and 94.9% of the benign and PCa groups, respectively (p=0.176). The Fokl Ff and Bsml bb genotypes, and Fokl FF and Bsml Bb genotypes were found to be more common in the PCa and benign groups, respectively. Apal Aa and Taql Tt were found to be more frequent in both groups. In patients with metastatic PCa; Bsml Bb genotype, Apal Aa genotype, and Taql Tt genotypes were found to be more common. Conclusion: Although Bsml Bb genotype, Apal Aa genotype, and Taql Tt genotypes were more commonly found in patients with metastatic PCa, further studies with increased sample sizes are needed to support this relationship in the Turkish PCa population. Keywords: Prostate cancer, vitamin D, gene polymorphism