학술논문
Oxidative Stress and Inflammation Are Associated With Age-Related Endothelial Dysfunction in Men With Low Testosterone
Clinical Research Article
Clinical Research Article
Document Type
Academic Journal
Author
Source
Journal of Clinical Endocrinology & Metabolism. February 2022, Vol. 107 Issue 2, p500, 15 p.
Subject
Language
English
ISSN
0021-972X
Abstract
Serum testosterone declines gradually with age at a rate of ~1% per year after the third decade (1). Data from the Baltimore Longitudinal Study of Aging indicate that 30% of [...]
Context: Vascular aging, including endothelial dysfunction secondary to oxidative stress and inflammation, increases the risk for age-associated cardiovascular disease (CVD). Low testosterone in middle-aged/older men is associated with increased CVD risk. Objective: We hypothesized that low testosterone contributes to age-associated endothelial dysfunction, related in part to greater oxidative stress and inflammation. Methods: This cross-sectional study included 58 healthy, nonsmoking men categorized as young (N = 20; age 29 [+ or -] 4 years; testosterone 500 [+ or -] 58 ng/dL), middle-aged/older with higher testosterone (N = 20; age 60 [+ or -] 6 years; testosterone 512 [+ or -] 115 ng/dL), and middleaged/older lower testosterone (N = 18; age 59 [+ or -] 8 years; testosterone 269 [+ or -] 48 ng/dL). Brachial artery fow-mediated dilation (FM[D.sub.BA]) was measured during acute infusion of saline (control) and vitamin C (antioxidant). Markers of oxidative stress (total antioxidant status and oxidized low-density lipoprotein cholesterol), inflammation (interleukin [IL]-6 and C-reactive protein [CRP]), and androgen deficiency symptoms were also examined. Results: During saline, FM[D.sub.BA] was reduced in middle-aged/older compared with young, regardless of testosterone status (P < 0.001). FM[D.sub.BA] was reduced in middle-aged/older lower testosterone (3.7% [+ or -] 2.0%) compared with middle-aged/older higher testosterone (5.7% [+ or -] 2.2%; P = 0.021), independent of symptoms. Vitamin C increased FM[D.sub.BA] (to 5.3% [+ or -] 1.6%; P = 0.022) in middle-aged/older lower testosterone but had no effect in young (P = 0.992) or middle-aged/older higher testosterone (P = 0.250). FM[D.sub.BA] correlated with serum testosterone (r = 0.45; P < 0.001), IL-6 (r = -0.41; P = 0.002), and CRP (r = -0.28; P = 0.041). Conclusion: Healthy middle-aged/older men with low testosterone appear to have greater age-associated endothelial dysfunction, related in part to greater oxidative stress and inflammation. These data suggest that low testosterone concentrations may contribute to accelerated vascular aging in men. Key Words: aging, testosterone, endothelial function, andropause, oxidative stress, inflammation
Context: Vascular aging, including endothelial dysfunction secondary to oxidative stress and inflammation, increases the risk for age-associated cardiovascular disease (CVD). Low testosterone in middle-aged/older men is associated with increased CVD risk. Objective: We hypothesized that low testosterone contributes to age-associated endothelial dysfunction, related in part to greater oxidative stress and inflammation. Methods: This cross-sectional study included 58 healthy, nonsmoking men categorized as young (N = 20; age 29 [+ or -] 4 years; testosterone 500 [+ or -] 58 ng/dL), middle-aged/older with higher testosterone (N = 20; age 60 [+ or -] 6 years; testosterone 512 [+ or -] 115 ng/dL), and middleaged/older lower testosterone (N = 18; age 59 [+ or -] 8 years; testosterone 269 [+ or -] 48 ng/dL). Brachial artery fow-mediated dilation (FM[D.sub.BA]) was measured during acute infusion of saline (control) and vitamin C (antioxidant). Markers of oxidative stress (total antioxidant status and oxidized low-density lipoprotein cholesterol), inflammation (interleukin [IL]-6 and C-reactive protein [CRP]), and androgen deficiency symptoms were also examined. Results: During saline, FM[D.sub.BA] was reduced in middle-aged/older compared with young, regardless of testosterone status (P < 0.001). FM[D.sub.BA] was reduced in middle-aged/older lower testosterone (3.7% [+ or -] 2.0%) compared with middle-aged/older higher testosterone (5.7% [+ or -] 2.2%; P = 0.021), independent of symptoms. Vitamin C increased FM[D.sub.BA] (to 5.3% [+ or -] 1.6%; P = 0.022) in middle-aged/older lower testosterone but had no effect in young (P = 0.992) or middle-aged/older higher testosterone (P = 0.250). FM[D.sub.BA] correlated with serum testosterone (r = 0.45; P < 0.001), IL-6 (r = -0.41; P = 0.002), and CRP (r = -0.28; P = 0.041). Conclusion: Healthy middle-aged/older men with low testosterone appear to have greater age-associated endothelial dysfunction, related in part to greater oxidative stress and inflammation. These data suggest that low testosterone concentrations may contribute to accelerated vascular aging in men. Key Words: aging, testosterone, endothelial function, andropause, oxidative stress, inflammation