부산대학교 도서관

We compared the effects of NF-[kappa]B inhibitor aurothiomalate and voltaren on NO production by mouse macrophages in vitro, their ability to cause local edema at the site of injection, and their effect on carrageenan-induced inflammation. High concentrations of aurothiomalate reduced NO production, while in low concentrations both aurothiomalate and voltaren stimulated this process. When injected into mouse footpad, aurothiomalate in a dose >1 mM and voltaren in a dose >1.6 [micro]M induce paw edema. Both compounds suppressed carrageenan-induced inflammation, but the efficacy of aurothiomalate 2-fold exceeded that of voltaren. Key Words: NF-[kappa]B; macrophage; nitric oxide carrageenan-induced inflammation
Inflammation is a global physiological response of the organism to pathogens. Impaired inflammation underlies the pathogenesis of the vast majority of human diseases, which necessitates the search for new pharmacological [...]