부산대학교 도서관

In the last decade, the inhibition of the mechanistic target of Rapamycin (mTOR) in renal clear cell carcinoma (RCC) has disappointed the clinician's expectations. Many clinical trials highlighted the low efficacy and unmanageable safety profile of first-generation mTOR inhibitors (Rapalogs), thus limiting their use in the clinical practice only to those patients who already failed several therapy lines. In this review, we analyze the major resistance mechanisms that undermine the efficacy of this class of drugs. Moreover, we describe some of the possible strategies to overcome the mechanisms of resistance and their clinical experimentation, with particular focus on novel mTOR inhibitors and the combinations of mTOR inhibitors and other anti-cancer drugs. Keywords: everolimus, temsirolimus, Rapa-Link, anti-angiogenics, autophagy
Introduction The treatment of metastatic Renal Cell Carcinoma (mRCC) has improved drastically over the last two decades. In fact, from a scarcity of specific therapeutic options, we assisted to the [...]