학술논문

Topoisomerase I as a target of erlotinib and gefitinib: efficacy of combined treatments with camptothecin
Document Type
Report
Source
International Journal of Oncology. March 1, 2014, Vol. 44 Issue 3, p934, 9 p.
Subject
Camptothecin -- Dosage and administration -- Patient outcomes
DNA topoisomerase I -- Health aspects
Erlotinib -- Dosage and administration -- Patient outcomes
Gefitinib -- Physiological aspects -- Dosage and administration -- Patient outcomes
Drug therapy, Combination -- Methods -- Patient outcomes
Drug targeting -- Methods -- Patient outcomes
Language
English
ISSN
1019-6439
Abstract
Abstract. Topoisomerases are essential nuclear enzymes that work to resolve topological problems that normally occur during DNA metabolism. Their involvement in crucial DNA associated-processes, such as replication, transcription and repair, [...]