부산대학교 도서관

Byline: X. Calvet (1), F. Baigorri (2), M. Duarte (2), P. Saura (2), C. Royo (2), D. Joseph (2), A. Mas (2), A. Artigas (2) Keywords: Key words Ranitidine; Gastric intramucosal pH; Tonometry; Critically ill patients Abstract: Objective: To determine whether ranitidine a) increases the values of gastric intramucosal pH (pHi) in critically ill patients, as determined by tonometry b) reduces the variability of these measurements. Design: Prospective, double blind, randomized, placebo-controlled study. Setting: General Intensive Care Unit of a teaching hospital. Patients: Twenty-five critically ill, mechanically ventilated patients requiring arterial catheter and nasogastric tube. Interventions: Tonometer placement blind, random administration of intravenous ranitidine (50 mg) or placebo. Measurements and main results: Tonometer saline PCO.sub.2 (PC[O.sub.2]i), arterial blood gases, gastric juice pH and pHi were determined immediately before, and 2, 4, 6 and 8 h after, ranitidine (12 patients) or placebo (13 patients). Ranitidine significantly increased gastric juice pH, but did not affect PC[O.sub.2]i or pHi pHi was 7.34 +- 0.14 before ranitidine, and 7.30 +- 0.12, 7.31 +- 0.11, 7.31 +- 0.14 and 7.31 +- 0.12 -- 2, 4, 6 and 8 h, respectively, after ranitidine administration (p = 0.55). Ranitidine did not modify the coefficients of variation of PC[O.sub.2]i or pHi, either. No significant changes in gastric juice pH, PC[O.sub.2]i or pHi were observed in the placebo group. Conclusions: In critically ill patients, ranitidine has no effect on pHi values, and does not increase the reproducibility of pHi measurements. Author Affiliation: (1) Department of Internal Medicine, Hospital de Sabadell, Parc Tauli s/n, E-08208 Sabadell, Barcelona, Spain Fax: + 34 (3) 7 23 38 63 E-mail: xcalvet@siberia.chpt.es, ES (2) Department of Intensive Care, Hospital de Sabadell, Parc Tauli s/n, E-08208 Sabadell, Barcelona, Spain, ES (3) Department of Cellular Biology and Physiology, Universidad Autonoma de Barcelona, Barcelona, Spain, ES Article note: Received: 24 October 1996 Accepted: 22 October 1997