학술논문
Integrated genomic and molecular characterization of cervical cancer
Document Type
Report
Author
Burk, Robert D.; Chen, Zigui; Saller, Charles; Tarvin, Katherine; Carvalho, Andre L.; Scapulatempo-Neto, Cristovam; Silveira, Henrique C.; Fregnani, Jos H.; Creighton, Chad J.; Anderson, Matthew L.; Castro, Patricia; Wang, Sophia S.; Yau, Christina; Benz, Christopher; Robertson, A. Gordon; Mungall, Karen; Lim, Lynette; Bowlby, Reanne; Sadeghi, Sara; Brooks, Denise; Sipahimalani, Payal; Mar, Richard; Ally, Adrian; Clarke, Amanda; Mungall, Andrew J.; Tam, Angela; Lee, Darlene; Chuah, Eric; Schein, Jacqueline E.; Tse, Kane; Kasaian, Katayoon; Ma, Yussanne; Marra, Marco A.; Mayo, Michael; Balasundaram, Miruna; Thiessen, Nina; Dhalla, Noreen; Carlsen, Rebecca; Moore, Richard A.; Holt, Robert A.; Jones, Steven J. M.; Wong, Tina; Pantazi, Angeliki; Parfenov, Michael; Kucherlapati, Raju; Hadjipanayis, Angela; Seidman, Jonathan; Kucherlapati, Melanie; Ren, Xiaojia; Xu, Andrew W.; Yang, Lixing; Park, Peter J.; Lee, Semin; Rabeno, Brenda; Huelsenbeck-Dill, Lori; Borowsky, Mark; Cadungog, Mark; Iacocca, Mary; Petrelli, Nicholas; Swanson, Patricia; Ojesina, Akinyemi I.; Le, Xuan; Sandusky, George; Adebamowo, Sally N.; Akeredolu, Teniola; Adebamowo, Clement; Reynolds, Sheila M.; Shmulevich, Ilya; Shelton, Candace; Crain, Daniel; Mallery, David; Curley, Erin; Gardner, Johanna; Penny, Robert; Morris, Scott; Shelton, Troy; Liu, Jia; Lolla, Laxmi; Chudamani, Sudha; Wu, Ye; Birrer, Michael; McLellan, Michael D.; Bailey, Matthew H.; Miller, Christopher A.; Wyczalkowski, Matthew A.; Fulton, Robert S.; Fronick, Catrina C.; Lu, Charles; Mardis, Elaine R.; Appelbaum, Elizabeth L.; Schmidt, Heather K.; Fulton, Lucinda A.; Cordes, Matthew G.; Li, Tiandao; Ding, Li; Wilson, Richard K.; Rader, Janet S.; Behmaram, Behnaz; Uyar, Denise; Bradley, William; Wrangle, John; Pastore, Alessandro; Levine, Douglas A.; Dao, Fanny; Gao, Jianjiong; Schultz, Nikolaus; Sander, Chris; Ladanyi, Marc; Einstein, Mark; Teeter, Randall; Benz, Stephen; Wentzensen, Nicolas; Felau, Ina; Zenklusen, Jean C.; Bodelon, Clara; Demchok, John A.; Yang, Liming; Sheth, Margi; Ferguson, Martin L.; Tarnuzzer, Roy; Yang, Hannah; Schiffman, Mark; Zhang, Jiashan; Wang, Zhining; Davidsen, Tanja; Olaniyan, Olayinka; Hutter, Carolyn M.; Sofia, Heidi J.; Gordenin, Dmitry A.; Chan, Kin; Roberts, Steven A.; Klimczak, Leszek J.; Van Waes, Carter; Chen, Zhong; Saleh, Anthony D.; Cheng, Hui; Parfitt, Jeremy; Bartlett, John; Albert, Monique; Arnaout, Angel; Sekhon, Harman; Gilbert, Sebastien; Peto, Myron; Myers, Jerome; Harr, Jodi; Eckman, John; Bergsten, Julie; Tucker, Kelinda; Zach, Leigh Anne; Karlan, Beth Y.; Lester, Jenny; Orsulic, Sandra; Sun, Qiang; Naresh, Rashi; Pihl, Todd; Wan, Yunhu; Zaren, Howard; Sapp, Jennifer; Miller, Judy; Drwiega, Paul; Murray, Bradley A.; Zhang, Hailei; Cherniack, Andrew D.; Sougnez, Carrie; Pedamallu, Chandra Sekhar; Lichtenstein, Lee; Meyerson, Matthew; Noble, Michael S.; Heiman, David I.; Voet, Doug; Getz, Gad; Saksena, Gordon; Kim, Jaegil; Shih, Juliann; Cho, Juok; Lawrence, Michael S.; Gehlenborg, Nils; Lin, Pei; Beroukhim, Rameen; Frazer, Scott; Gabriel, Stacey B.; Schumacher, Steven E.; Leraas, Kristen M.; Lichtenberg, Tara M.; Zmuda, Erik; Bowen, Jay; Frick, Jessica; Gastier-Foster, Julie M.; Wise, Lisa; Gerken, Mark; Ramirez, Nilsa C.; Danilova, Ludmila; Cope, Leslie; Baylin, Stephen B.; Salvesen, Helga B.; Vellano, Christopher P.; Ju, Zhenlin; Diao, Lixia; Zhao, Hao; Chong, Zechen; Ryan, Michael C.; Martinez-Ledesma, Emmanuel; Verhaak, Roeland G.; Averett Byers, Lauren; Yuan, Yuan; Chen, Ken; Ling, Shiyun; Mills, Gordon B.; Lu, Yiling; Akbani, Rehan; Seth, Sahil; Liang, Han; Wang, Jing; Han, Leng; Weinstein, John N.; Bristow, Christopher A.; Zhang, Wei; Mahadeshwar, Harshad S.; Sun, Huandong; Tang, Jiabin; Zhang, Jianhua; Song, Xingzhi; Protopopov, Alexei; Shaw, Kenna R. Mills; Chin, Lynda; Olabode, Oluwole; DiSaia, Philip; Radenbaugh, Amie; Haussler, David; Zhu, Jingchun; Stuart, Josh; Chalise, Prabhakar; Koestler, Devin; Fridley, Brooke L.; Godwin, Andrew K.; Madan, Rashna; Ciriello, Giovanni; Martinez, Cathleen; Higgins, Kelly; Bocklage, Therese; Auman, J. Todd; Perou, Charles M.; Tan, Donghui; Parker, Joel S.; Hoadley, Katherine A.; Wilkerson, Matthew D.; Mieczkowski, Piotr A.; Skelly, Tara; Veluvolu, Umadevi; Hayes, D. Neil; Rathmell, W. Kimryn; Hoyle, Alan P.; Simons, Janae V.; Wu, Junyuan; Mose, Lisle E.; Soloway, Matthew G.; Balu, Saianand; Meng, Shaowu; Jefferys, Stuart R.; Bodenheimer, Tom; Shi, Yan; Roach, Jeffrey; Thorne, Leigh B.; Boice, Lori; Huang, Mei; Jones, Corbin D.; Zuna, Rosemary; Walker, Joan; Gunderson, Camille; Snowbarger, Carie; Brown, David; Moxley, Katherine; Moore, Kathleen; Andrade, Kelsi; Landrum, Lisa; Mannel, Robert; McMeekin, Scott; Johnson, Starla; Nelson, Tina; Elishaev, Esther; Dhir, Rajiv; Edwards, Robert; Bhargava, Rohit; Tiezzi, Daniel G.; Andrade, Jurandyr M.; Noushmehr, Houtan; Gilberto Carlotti, Carlos, Jr; Tirapelli, Daniela Pretti da Cunha; Weisenberger, Daniel J.; Van Den Berg, David J.; Maglinte, Dennis T.; Bootwalla, Moiz S.; Lai, Phillip H.; Triche, Timothy, Jr; Swisher, Elizabeth M.; Agnew, Kathy J.; Shelley, Carl Simon; Laird, Peter W.; Schwarz, Julie; Grigsby, Perry; Mutch, David
Source
Nature. March 16, 2017, Vol. 543 Issue 7645, p378, 7 p.
Subject
Language
English
ISSN
0028-0836
Abstract
Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary cervical cancers, one of the largest comprehensive genomic studies of cervical cancer to date. We observed notable APOBEC mutagenesis patterns and identified SHKBP1, ERBB3, CASP8, HLA-A and TGFBR2 as novel significantly mutated genes in cervical cancer. We also discovered amplifications in immune targets CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2), and the BCAR4 long non-coding RNA, which has been associated with response to lapatinib. Integration of human papilloma virus (HPV) was observed in all HPV18-related samples and 76% of HPV16-related samples, and was associated with structural aberrations and increased target-gene expression. We identified a unique set of endometrial-like cervical cancers, comprised predominantly of HPV-negative tumours with relatively high frequencies of KRAS, ARID1A and PTEN mutations. Integrative clustering of 178 samples identified keratin-low squamous, keratin-high squamous and adenocarcinoma-rich subgroups. These molecular analyses reveal new potential therapeutic targets for cervical cancers.
Author(s): The Cancer Genome Atlas Research Network; Albert Einstein College of Medicine; Robert D. Burk [1]; Zigui Chen [1]; Analytical Biological Services; Charles Saller [2]; Katherine Tarvin [2]; Barretos Cancer [...]
Author(s): The Cancer Genome Atlas Research Network; Albert Einstein College of Medicine; Robert D. Burk [1]; Zigui Chen [1]; Analytical Biological Services; Charles Saller [2]; Katherine Tarvin [2]; Barretos Cancer [...]